Naturalproductman’s Blog

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The Synthesis of 12alpha-Hydroxy Steroids

Posted by naturalproductman on November 3, 2018

Francis Yoshimoto and co-workers at the University of Texas at San Antonio reported in Steroids on the synthesis of 12alpha-hydroxy steroid derivatives to biochemically characterize P450 8B1, the enzyme implicated in cardiovascular health and obesity. Both 7-keto DHEA and 12alpha-hydroxy 7-keto DHEA had antagonistic properties towards the NMDA receptor.

Screen Shot 2018-11-03 at 3.27.25 PM

 

Steroids paper

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