Total Synthesis of Vinigrol
Posted by naturalproductman on October 30, 2009
Well it’s been done – vinigrol has been around since 1987 and Phil Baran’s group at Scripps has finally reported the synthesis for the molecule. A key step in this synthesis is the bromonitrile [3+2] cycloaddition to install the methyl-hydroxy equivalent accross an olefin.
Leave a comment